Science and medicine

Crohn’s Disease

Crohn’s Disease (CD) is an autoimmune disease of the gastrointestinal tract. Any part of the digestive tract can be affected. The inflammation often spreads deep into the layers of affected bowel tissue. The disease can be both painful and debilitating, and sometimes may lead to life-treatening complications. Crohn’s Disease affects men and women equally and seems to run in some families. The most common symptoms of Crohn’s disease are abdominal pain and diarrhea. Current medication can help control Crohn’s disease and make recurrences less frequent, but no cure exists. The cause of Crohn’s Disease is unknown but researchers believe it is the result of an abnormal reaction by the immune system. FFP104 is expected to interfere with this abnormal immune reaction, hereby inducing long-term remission, and lowering the risk for developing complications and the requirement for surgery.

Ch5D12, the precursor molecule of FFP104 was already tested in a clinical study with subjects suffering from CD. 18 CD patients were enrolled into 4 dose cohorts. A significant decrease of the CDAI score was observed after a single dose of ch5D12. Details of this ch5D12 study can be found in the Kasran paper under NEWS AND MORE – READING ROOM.